Vancomycin Vitamin

Paramagnetic ion probes have been successfully used to study the binding characteristics and solution conformations of a number of biochemically important molecules. These include vitamin D, (533) penicillins, (534) and the antibiotics tetracycline, (535-537) vancomycin, (632) and bacitracin. (633) Antibodies and antibody fragments (immunoglobulins, IgG) have been studied by proton relaxation enhancement methods when lanthanide ions, particularly Gd(m), are bound to the proteins. (746-748). 

Interventions to ameliorate the nephrotoxicity observed with vancomycin have largely been confined to the laboratory and have focused on attenuating oxidative stress. Oxidative stress has been postulated as the primary mechanism in the pathogenesis of vancomycin-induced nephrotoxicity [200]. A study by Ocak et al tested a diverse group of antioxidants that included caffeic acid phenethyl ester (CAPE), vitamin C, vitamin E and N-acetylcysteine [198]. Each of these agents were... 

Ocak S, Gorur S, Flakverdi S, Celik S, Erdogan 5, Protective effects of caffeic acid phenethyl ester, vitamin C, vitamin E and N-ace-tylcysteine on vancomycin- induced nephrotoxicity in rats, Basic Clin Pharmacol Toxicol, 2007,100 328-333. 

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