Valinol: 1-Butanol, 2-amino-3-methyl

Valinol 1-Butanol, 2-amino-3-methyl-, L (8) l-6utanol, 2-amino-3-methyl-,... 

In a later report1, a total of 13 different auxiliaries were tested. These were based mainly on O-silylated or alkylated /1-amino alcohols, the precursors of which were available commercially or by reduction of a-amino acids. The /1-amino alcohols used were, for example, both enantiomers of 2-amino-3-methyl-l-butanol (valinol), (A)-2-amino-l-propanol (alaninol), (A)-... 

Chiral 2-thiazolidinethiones, e.g., 40, prepared from cysteine esters by the reaction with carbon disulfide23, are used for the enantiotopic differentiation of methylene groups (Section C.). Similarly, carbon disulfide reacts with amino alcohols such as (5)-2-amino-J-butanol or (S)-2-amino-3-methyl-1-butanol (valinol) to give the 2-thiazolidinethiones (S)-ETT 42 and (S)-IPTT 4124 which have been used as auxiliaries (after Y-acylation with carboxylic acids and dicyclo-hexylcarbodiimide) in acylimonium ion cyclizations (Section D.I.4.5.). 

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