Validamine structure

Synthetic studies of validamycins were initially devoted to establishing the structure of validamycin A. The structure in which a ) -D-glucopyranosyl group is attached to 0-3 of the validamine residue was initially proposed on the basis of degradative studies. However, the original structure was re-... 

The majority of naturally occurring aminocarbasugars bears the amino functionality located at the pseudoanomeric position however, replacement of one or more hydroxyl groups by amino functions on the carbasugar backbone may offer great opportunities for structural and stereochemical variation. This section is subdivided into three subsections, dealing with the synthesis of validamine, valiolamine, and valienamine-type carbaglycosyl amine structures. 

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