Valid analytical measurements summary

In summary, the purpose of any validated analytic method is to obtain consistent, reliable, and accurate measurements. The results from method validation can be used to judge the quality, reliability, and consistency of analytic results, which is an integral part of any good analytic practice and the base of which is supported by the identification and quantification of active substances, studies of their fate and behavior, and studies of their residue. Validation of analytic methods is required by actual EU legislative framework and has received considerable attention in the literature from industrial committees and regulatory agencies. 

In summary, HX-MS measurements of Type A analytes can be firmly based in the SI, and the HX-MS instmment and analysis method can be traced through the calibration hierarchy to fundamental standards. Assured that this rigorous foundation can exist, the development of validated measurement methods and RM for use in proteolytic fragmentation HX-MS is sensible. 

The ATP describes predefined method performance criteria that any analytical method must meet to be used for the described purpose. It is a prospective summary of the performance characteristics of a measurement system. The ATP is used to direct initial method development as well as any subsequent changes to the method over the lifecycle of the product or analyte. The ATP can be structured so that it is independent of the t52pe of analytical technique, and just as with traditional validation, a method must be shown to meet the ATP criteria before it can be used. 

Naturally, it is difficult to predict the evolution of a discipline as diverse as analytical chemistry. Table XIV indicates a summary of short-term future directions as garnered from the present interests and activities of researchers in the field. One dramatic, rapid change is the movement away from sampling technology. Direct in situ measurement technology is being emphasized in many areas of analytical chemistry and eventually may largely supercede the need to define statistically valid samples from a bulk sample material. 

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