Vaginal and uterine drug delivery

Sustained- and controlled-release devices for drug delivery in the vaginal and uterine areas are most often for the delivery of contraceptive steroid hormones. The advantages in administration by this route—prolonged release, minimal systemic side effects, and an increase in bioavailability—allow for less total drug than with an oral dose. First-pass metabolism that inactivates many steroid hormones can be avoided [183,184],... 

Robinson JR, Rathbone MJ. Mucosal drug delivery— rectal uterine and vaginal. In Mathiowitz E, ed. Encyclopedia of Controlled Drag Delivery. New York John Wiley and Sons, 1999. 

Oxytocic drag s are drug s that are used in antepartum (before birth of the neonate) to induce uterine contractions similar to those of normal labor. These dragp are desirable when early vaginal delivery is in the best interest of the woman and the fetus. 

Muscle Isoflurane produces some relaxation of skeletal muscle via its central effects. It also enhances the effects of depolarizing and nondepolarizing muscle relaxants. Isoflurane is more potent than halothane in its potentiation of neuromuscular blocking agents. The drug relaxes uterine smooth muscle and is not recommended for analgesia or anesthesia for labor and vaginal delivery. 

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