Vacor toxicity

II. Toxic dose. Acute toxicity has usually occurred after ingestion of one 39-g packet of Vacor (approximately 8 g of PNU). The smallest dose rejxrrted to cause toxicity was 390 mg. 

II. Indications. Nicotinamide is used to prevent the neurologic and endocrinologic toxicity associated with the ingestion of Vacor (PNU), a rodenticide that is believed to act by antagonizing nicotinamide (see p 361). Best results are achieved when nicotinamide therapy is instituted within 3 hours of ingestion. It may also be effective for treatment of Vacor analogs such as alloxan and streptozocin. 

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