UV-Exposed Proteins Failed to Form Amyloid De Novo

4 UV-Exposed Proteins Failed to Form Amyloid De Novo 

As discussed earlier, conformational change/structural perturbation is a prerequisite for amyloid formation. Exposure to UV light did not initiate the fibril formation it led to amorphous aggregation of prion protein and no observable change to the other two proteins. We have employed conditions that are known to favor amyloid fibril formation and investigated the effect of UV light exposure of these proteins on their ability to form amyloid fibrils. 

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