Uterine contractility, prostaglandin

Elevated prostaglandin levels are present in the endometrial fluid of dysmenor-rhoeic women and correlate well with the degree of pain. NSAIDs are inhibitors of prostaglandin synthesis and probably work by decreasing uterine prostaglandin levels and uterine contractility. 

In that paper, we suggested for the first time that GA effects were related to inhibition of calcium uptake by smooth muscle and that indeed GA could be seen as a calcium channel blocker. This compoimd affected the contractile uterine responses in several species including human uterine smooth muscle [34]. GA also caused inhibition in the responses elicited by a number of spasmogenic compounds including acetylcholine, prostaglandins and even oxytocin "Fig. (5)." These drugs are known to enhance calcium influx by different but linked signal transduction pathways. 

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