Using Inorganic Reagents in Organic Reactions

2 Aromatic Fluorinations Under Phase Transfer Conditions 

Many fluorinated aromatic molecules have physiological activity and therefore have agricultural and pharmaceutical applications. An important synthetic 

Rate enhancements for these types of reaction have been reported to be as high as 200-fold, and the selectivity of the reaction was found to be very substrate dependent. These reactions must be conducted in dipolar aprotic solvents in the absence of water. Although tetramethylammonium chloride is too polar to find widespread application as a phase transfer agent, it has good thermal stability, and this, combined with its low cost, has resulted in its large scale industrial use in phase transfer catalysed aromatic nucleophilic fluorinations. 

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