Use of Ionic Liquids as Heating Aids

The third reaction studied was the alkylation of pyrazoles with alkyl halides. This reaction was not possible using the ionic liquid heating technique, because the aryl halide reacted with the ionic liquid at the elevated temperatures used in the reaction. This highlights one of the limitations of this method. 

For books on microwave activation in synthesis (a) Kappe, O. Stabler, A. Microwaves in Organic and Medicinal Chemistry, 2005, Wiley-VCH, Weinheim (b) Tierney, J. P. Lidsteom, P. Eds. Microwave Assisted Organic Synthesis, 2005, Blackwell, Oxford (c) Loupy, A. Ed. Microwaves in Organic Synthesis, 2002, Wiley-VCH, Weinheim (d) Hayes, B. L., Microwave synthesis Chemistry at the Speed of Light, 2002, CEM Publishing, Matthews. 

Texiee-Boullet, F. Jacquault, P. Mathe, D. Synthesis 1998, 1213-1235 (e) Caddick, S., Tetrahedron, 1995, 

8 For an introduction to ionic liquids see Wasserscheid, P. Welton, T. Ionic liquids in Synthesis, 2003, Wiley VCH, Weinheim. 

52 Bosgh, a. I. DE lA Ceuz, P. Diez-Paeea, E. Loupy, A. Langa, E. 

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