Use of Allometry to Predict Human Pharmacokinetic Parameters

Method I If the exponent lies between 0.55 and 0.7, then Equation 30.1 can be applied without correction. 

Method II If the exponent lies between 0.7 and 1.0, the allometric equation for predicting clearance is normalized according to the maximum life span potential for each animal species, as initially proposed by Boxenbaum (7). 

Recently, a more comprehensive analysis of allometric scaling results for 103 drugs in three species 

---