Urine urinary organic acid profil

Fig. 11.10 Chromatogram of organic acids extracted using DEAE-Sephadex from the urine of the same patient described in the legend to Fig. 11.9, after 1 year on vitamin B12 therapy. Separated as described for Fig. 11.9. Peak identifications are given in the legend to Fig. 11.9, additional identifications are 10, 2-deoxytetronate 17,4-hydroxyphenyl-acetate 18, 2-deoxypentonate. The reduced excretion of methylmalonate and the abolition of methylcitrate and 3-hydroxypropionate excretion together with the production of an otherwise normal urinary organic acid profile is apparent when compared to Fig. 11.9. (The horizontal axis represents the time elapsed in minutes from sample injection.) (Redrawn from the original, after Chalmers, 1980)...

Table 7.2 Urinary organic acids identified during metabolic profiling by GC-MS of normal urine (from Homing and Horning, 1971a,b).

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