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Uridine diphosphate glucuronic acid UDPGA

Typical reactions catalyzed by UGT enzymes require the cofactor uridine diphosphate-glucuronic acid, UDPGA. However, the C-terminus of all UGT enzymes contains a membrane-spanning domain that anchors the enzyme in the endoplasmic reticulum, and the enzyme faces the lumen of the endoplasmic reticulum, where it is ideally placed to conjugate lipophilic xenobiotics and their metabolites generated by oxidation, reduction, or hydrolysis. The lumenal... [Pg.342]

Uridine diphosphate glucuronosyltransferase catalyzes the transfer of glucuronic acid from uridine diphosphate glucuronic acid (UDPGA) to various... [Pg.287]

Conjugation reactions in which electrophilic adenosine-containing cofactors such as ATP, phosphoadenosine phosphosulfate (PAPS), acet-ylcoenzyme A (acetylCoA), uridine diphosphate glucuronic acid (UDPGA), or S-adenosylmethio-nine (SAM) react with nucleophilic groups such as -OH or -NHg... [Pg.138]

Uridine diphosphate glucuronic acid (UDPGA) + 2NADH2 3. a. O Glucuronide formation... [Pg.104]

See other pages where Uridine diphosphate glucuronic acid UDPGA is mentioned: [Pg.201]    [Pg.102]    [Pg.236]    [Pg.167]    [Pg.169]    [Pg.47]    [Pg.221]    [Pg.154]    [Pg.1928]    [Pg.236]    [Pg.683]    [Pg.217]    [Pg.190]    [Pg.551]    [Pg.129]    [Pg.683]    [Pg.317]    [Pg.163]    [Pg.147]    [Pg.257]    [Pg.581]    [Pg.104]   


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Glucuronate

Glucuronate/glucuronic acid

Glucuronates

Glucurone

Glucuronic

UDPGA

Uridine diphosphate glucuronate acid

Uridine diphosphate glucuronic acid

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