Uridine diphospate-2-acetamido-2-deoxy

As mentioned, the insecticides inhibit chitin synthesis indirectly and they are not useful as fungicides. Polyoxins, however, are structural analogues to uridine diphospate-2-acetamido-2-deoxy-D-glucose, which is the substrate for chitin synthetase, and inhibit the incorporation of 2-aceta-mido-2-deoxy-D-glucose into chitin. It is produced by fermentation of Strep-tori n/ces cacaoi var. asoensis. It is used as a fungicide against powdery mildews in apples and pears, and for many other purposes. Its mammalian toxicity is very low, and it has a no-observed-effect level (NOEL) in rats of 44,000 mg/kg in diet in 2-year studies. The compounds inhibit chitin synthetase from insects, but are not toxic to insects in vivo. 

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