Uracil, amino mustard

Avoid the use of mustard attached to normal body constituent chemicals (e.g., amino acids, uracil). 

N,N-BIS(2-CHLOROETHYL)AMINOURACIL CB-4835 CHLORETHAMINACIL DEMETHYIDOPAN DESMETHYLDOPAN 5-pi-(P-CHLOROETHYL)-AMINO)URACIL 5-pi-2-CHLOROETHYL)AMINO-URACIL 2,6-DIHYDROXY-5-BIS(2-CHLOROETHYL)-AMINOPYRAMIDINE ENT 50,439 NCI-C04820 NORDOPAN NSC-34462 RCRA WASTE NUMBER U237 OSK-19849 U-8344 URACILLOST URACILMOSTAZA URACIL MUSTARD URAMUSTIN... 

Another means of taking advantage of the transport proteins is to attach the active drug to an amino acid or nucleic acid base such that the drug gets a piggyback across the membrane. Uracil mustard (Fig. 8.23) is one such example. 

The biological importance of uracil, relative to nucleic acid and protein syntheses, led to its early selection as a candidate carrier [478]. Uracil mustard (5-(bis-(/S-chloroethyl)amino)uracil, XCVIa) can be synthesised by the treatment of 5-aminouracil with ethylene oxide in aqueous acetic acid, followed by the chlorination of the resulting 5-(bis-()5-hydroxyethyl)amino) uracil with thionyl chloride in diglyme [479, 480]. 

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