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Uptake cyclodienes

As with other cyclodiene insecticides, heptachlor blocks the neuronal uptake of chloride ions by blocking the activity of y-aminobutyric acid. This results in only a partial repolarization of activated neurons leading to an uncontrolled excited condition. Additionally, chlordane inhibits Ca, Mg -adenosine triphosphatase (ATPase) and Na,K-ATPase functions, leading to increased concentrations of... [Pg.1313]

Recent studies have grouped lindane with the cyclodienes on the basisLjaf its potent and stereospecific inhibition of [3H]DHPTX (.2,3) and [3DS]TBPS (4 J>) binding. However, the quantitative correlations between potency in the chloride flux assay, potency in the [3 >S]TBPS binding assay, and acute toxicity that were observed for the cyclodienes do not extend to lindane. Lindane was a very weak inhibitor of chloride uptake (I 1 mM J7). Inclusion of the data... [Pg.105]

See other pages where Uptake cyclodienes is mentioned: [Pg.130]    [Pg.96]    [Pg.1885]    [Pg.103]    [Pg.104]    [Pg.105]    [Pg.105]    [Pg.109]    [Pg.109]   
See also in sourсe #XX -- [ Pg.117 , Pg.130 ]



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Cyclodiene

Cyclodienes

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