Unsubstituted nitroolefins

Kobayashi et al. studied the alkaloid-catalyzed addition of thioglycolic acid to trans-yfi-nitrostyrenes and other nitroolefins [57a]. Under carefully controlled reaction conditions 58% ee was achieved in the addition of thioglycolic acid to (unsubstituted) trans-fl-nitrostyrene and 37% ee for a non-aromatic nitroolefin. Similar... 

The asymmetric catalysis of the phosphonium aryloxide-arylhydroxide assembly 21 was also applicable to the y-selective conjugate addition of C2-unsubstituted azlactone to nitroolefins, where use of a polar solvent system was crucial for sufficient reaction efficiency and stereoselectivity (Scheme 19) [36]. Various... 

The organocatalytic activation of electrophiles through (double) hydrogen bonding has been exploited in the transfer hydrogenation of imines and nitroolefins using Hanztsch esters. Unsubstituted thiourea was reported as efficient catalyst for the one-pot reductive animation of both aldehydes [77] and ketones [78] with various... 

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