Unnatural amino adds

Caligiuri, A., D Arrigo, P., Rosini, E Tessaro, D., Molla, G., Servi, S. and Polle-gioni, L. (2006) Enzymatic conversion of unnatural amino adds by yeast D-amino add oxidase. Advanced Synthesis Catalysis, 348, 2183-2190. 

Benz, P. and Wohlgemuth, R. (2007) Amino acid oxidase-catalysed resolution and Pictet-Spengler reaction towards chiral and rigid unnatural amino adds. Journal of Chemical Technology and Biotechnology (Oxford, Oxfordshire 1986), 87,1082-1086. 

Fotheringham, I., Archer, I., Carr, R., Speight, R. and Turner, N.J. (2006) Preparative deracemization of unnatural amino adds. Biochemical Society Transactions, 34, 287-290. 

Unnatural Amino Adds to Investigate Biologic Processes... 

Bacterial cell walls contain the unnatural amino add D-alanine. If you wanted to prepare a sample of D-ala, how would you go about it Hint. There is not enough In bacteria to make that a worthwhile source, but have you done Problem 8 yet )... 

Contrary to the superficial perception that (D)-amino acids are unnatural amino adds, for many organisms they instead play a vital role. Thus, there exists indeed a whole arsenal of synthetic methods and enzymes to generate these unusual amino acids. [72] For instance, (D)-alanine and (D)-glutamic acid are essential for the formation of bacterial peptidoglycans. But (D)-amino acids have also been discovered in fungi, algae, higher plants, amphibians and even in mammals. 

Improvements to protein expression. Whilst many of the advances in studying biomolecules by NMR are as a direct result of developments in sample labelling schemes, such as isotope enrichment at specific sites or unnatural amino add incorporation (yide infra), there are still great improvements that can be made to routine protein expression methods. For conventional and perdeuteration, Li et al. describe optimisation of... 

The enantioselective Rh-catalyzed addition of aryl boronic acids to dehydroala-nine has also been performed in the presence of C2-symmetric aryl diphosphite ligands allowing the synthesis of unnatural amino add esters such as 109 in moderate enantioselectivity (Scheme 3.52) [78[. 

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