Unidimensional codes

Topological indices are used to describe some components of connectivity. A more complete description is afforded by unidimensional codes (linear line notations) such as SMILES. Connectivity plus explicit attention to valence electrons is afforded by the electrotopological indices... 

In this chapter we described and illustrated only a few unidimensional search methods. Refer to Luenberger (1984), Bazarra et al. (1993), or Nash and Sofer (1996) for many others. Naturally, you can ask which unidimensional search method is best to use, most robust, most efficient, and so on. Unfortunately, the various algorithms are problem-dependent even if used alone, and if used as subroutines in optimization codes, also depend on how well they mesh with the particular code. Most codes simply take one or a few steps in the search direction, or in more than one direction, with no requirement for accuracy—only that fix) be reduced by a sufficient amount. 

The problem of understanding the mechanism of protein folding, briefly described above, is essentially a problem of decoding a code. This code governs the translation of the unidimensional information contained in the sequence of amino acids to the three-dimensional information expressed in the native structure. This code is undoubtedly very complex and many experiments (1,6,18) point to the importance of... 

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