Understanding the Heteronuclear Multiple-Bond Correlation HMBC Pulse Sequence

9 UNDERSTANDING THE HETERONUCLEAR MULTIPLE-BOND CORRELATION (HMBC) PULSE SEQUENCE 

The HMBC experiment is just an HMQC experiment with the 1/(2J) delay set for a J value of about 10 Hz (typical for two- and three-bond 7ch) rather than 150 Hz (typical 

The refocusing delay just before acquisition has been eliminated, so the peaks in F2 will be antiphase doublets separated by the long-range/cH (2-15 Hz). This splitting is in addition to any H splitting pattern already present in the ID proton spectrum (Fig. 11.11). The second 13 C 90° pulse is phase cycled as before to make sure that only H magnetization 

INVERSE HETERONUCLEAR 2D EXPERIMENTS HSQC, HMQC, AND HMBC 

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