Ugi Postmodification Processes

One of the best strategies for the synthesis of valuable pharmaceutical compounds and also for the rapid generation of molecular diversity is the use of isocyanide-based multi-component reactions (IMCRs) [3-8]. More specifically. 

Balalaie et al. described in 2010 a six-component reaction. The stereoselective synthesis of oxindole derivatives was carried out using a sequential one-pot Ugi/Heck carbocyclization/ 

SCHEME 7.33 Synthesis of nitrogen heterocycles by Ugi/aldol sequence. 

SCHEME 7.34 Synthesis of oxindoles 84 using a one-pot Ugi/Heck carbocyclization/Sonogashira/nucleophilic addition. 

Very recently, the synthesis of benzo-l,4-diazepin-2,5-diones was reported, using the Ugi-4CR postmodification 

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