Ugi four-center three-component reaction

Alicyclic P-lactams 28 were successfully synthesized via a parallel liquid-phase Ugi four-center three-component reaction, starting from alicyclic P-amino acids such as cis-2-aminocyclohexanecarboxylic acid, c/.s-2-aminocyclopentanecarboxylic acid, 2,3-diexo-3-aminobicyclo-[2.2.1]heptane-2-carboxylic acid and some of their partially unsaturated analogues <02OL1967>. 

M.A. Rasouli, M. Mahdavi, PR. Ranjbar, M. Saieedi, A. Shafiee, A. Foroumadi, A green one-pot synthesis of N-aIkyl-2-(2-oxoazepan-l-yl)-2-arylacetamide derivative via an Ugi four-center three-component reaction in water. Tetrahedron Lett. 53 (2012) 7088-7092. 

The synthesis of fused alicyclic ft-lactams by the four-center three-component Ugi reaction (U-4C-3CR) on a solid support has been reported. Also, resins have been used as scavengers in the purification of fused /3-lactams prepared in the solution phase <2004MI215>. 

Scheme 20 Synthesis of 2,5-DKPs via Ugi three-center four-component reaction with two representative 3D conformations of 123A (blue) and 123B cyan). Yield shown represents yield overall steps...

Scheme 6 Three-component four-center Ugi reaction to (3-lactam...

Four-component Coupling Reactions. TMSA is one of the components in the Ugi-five-center-four-component reaction (U-5C-4-CR). The other three conponents for this reaction are an amine, an isocyanide, and an oxo-component, such as aldehyde or ketone. The reaction is usually carried out in methanol and provides tetrazoles in moderate to good yields. ... 

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