Tyrosine three component Mannich-type

N.S. Joshi, L.R. Whitaker, M.B. Francis, A three-component Mannich-type reaction for selective tyrosine bioconjugation, J. Am. Chem. Soc. 2004, 126,15942-15943. 

Fig. 10.3-5 Tyrosine modification using a when proteins are treated alone with either three component Mannich-type reaction. component, (b) The reaction conversion is (a) Aldehydes and anilines condense to listed for a number of anilines and aliphatic form imines in situ, which react with tyrosine amines using a-chymotrypsinogen A as the residues through an electrophilic aromatic substrate and formaldehyde as the aldehyde substitution reaction. No reaction occurs component.

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