Type PD Production Methods

Promoted by CuI/2-hydroxybenzohydrazide catalytic system, a variety of pyr-rolo[l,2-a]quinoxalines have been efficiently one-pot synthesized from pyrtole-2-carboxaldehyde and 2-haloanilines in moderate to excellent yields (Table 3.8) (Li et al. 2015). 

As shown in Table 3.8, the cascade reactions were performed well enough for most of 2-iodoanilines with electronrich, electron-neutral, and electron-poor groups to afford corresponding pyrrolo[l,2-ti]quinoxalines in good to excellent yields (entries 1-7). Moreover, heterocyclic aminoiodoarene could also react well enough with a 78 % yield (entry 8). Additionally, aminobromoarene provided a 68 % yield, while aminochloroarene afforded only a trace of the product under the experimental conditions (entries 9 and 10). 

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