Type N Syntheses

Type N (N—C—C—S—C) Syntheses.—The well-known cyclization of the radioprotective S-aminomethylisothiouronium bromide hydrobromide (AET) into 2-amino-A -thiazoline (2-AT) has been studied kinetically by 

4-Disubstituted thiazolin-5-ones may have one of structures (113)—(116). According to its speptral properties, 4-isopropyl-2-phenylthiazolinone must be represented by (113) rather than (114). I.r. and n.m.r. measurements 

The structures of the isomeric 2-arylamino-A -thiazolines bearing a methyl group on their extranuclear or ring nitrogen, (117) and (118), may be assigned on the basis of their n.m.r. spectra, specifically by the signals of 

The photoisomerization of A -thiazolines to N-alkenylthioamides (119) has been briefly reported. 2,4,4-Trimethyl-A -thiazoline, as well as its 

5-isomer, produces a mixture of MeCSNHCH=CMez and MeCSNHCH2CMe=CH2- Feasible mechanisms for each of the processes were considered.  

---