Tuberculum olfactorium

Dopamine is formed from tyrosine by hyclroxylation with tyrosine hydroxylase and the removal of a CO2 group by aromatic amino acid decarboxylase. The catecholamine is found in high concentrations in parts of the brain—the caudate nucleus, the median eminence, the tuberculum olfactorium, and the nucleus accumbens. Dopamine appears to act as an inhibitory neurotransmitter. 

The S-HTja receptor is labeled in high concentration in the prefrontal cortex, claustrum, neocortex [in human cortex mainly in layer 111 and V], tuberculum olfactorium, nucleus accumbens, and the posterolateral extension of the caudate nucleus. In the neocortex, receptors have been also detected... 

Quarfordt SO, Kalmus GW, Myers RD (1991) Ethanol drinking following 6-OFIDA lesions of nucleus accumbens and tuberculum olfactorium of the rat. Alcohol 5 211-217. 

Fig. 3.4. Significant enhancement of dopamine release from the substantia nigra, tuberculum olfactorium, and striatum of rats, respectively, isolated 30 min after the subcutaneous administration of a single dose of (-)-deprenyl. The amount of dopamine released from the tissue within 20 min following the administration of different doses of (-)-deprenyl was measured according to Knoll and Miklya (1995). Horizontal lines to the right of the graph bars show the SEM. Paired Student s f-test. P < 0.05, P < 0.02, P < 0.01...

The amount of serotonin released in 4-week-old rats was 7-fold higher in males and 6-fold higher in females than in 2-week-old animals. Thereafter, the amount of serotonin released from the raphe decreased with time, but remained significantly higher than in 2-week-old rats. In contrast, the amount of dopamine released from the striatum or tuberculum olfactorium of 16- to 32-week-old rats did not differ from that measured in 2-week-old animals. The amount of norepinephrine released from the locus coeruleus of 16- to 32-week-old rats was significantly lower than that in 2-week-old animals. 

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