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Tschemiac-Einhom reaction

An alternate route to substituted tetrahydrobenzazepines (Scheme 33) commenced with the Michael addition of the ester 351 to acrylonitrile in the presence of Triton B, and the intermediate cyanoester was converted to 352 by reduction of the ester function with lithium borohydride and O-benzylation (168). Base-induced hydrolysis of the nitrile group of 352 delivered the corresponding acid, which was transformed to 353 via a Curtius rearrangement. Subjection of 353 to a modified two-step Tschemiac-Einhom reaction involving AMiydroxymethyla-tion and subsequent acid-catalyzed cyclization gave 354. [Pg.319]

Tschemiac-Einhom Reaction Tschugaeff Olefin Synthesis Tsuii-Trost Reaction Twitchell Process Ugi Reaction... [Pg.16]

See other pages where Tschemiac-Einhom reaction is mentioned: [Pg.368]    [Pg.336]    [Pg.5]    [Pg.244]    [Pg.285]    [Pg.368]    [Pg.336]    [Pg.5]    [Pg.244]    [Pg.285]    [Pg.316]   
See also in sourсe #XX -- [ Pg.654 ]

See also in sourсe #XX -- [ Pg.654 ]



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