Tritium NMR spectroscopy

The distribution of tritium in compounds 137-150 can be determined by tritium NMR spectroscopy without chemical manipulations115. The structure retention index relationship (SR IR)116 has been used for identification of unknown radioactive peaks and to differentiate by-products from radioimpurities from extraneous sources. 

Evans, EA, DC Warrell, JA Elvidge and JR Jones, Handbook of Tritium NMR-Spectroscopy and Applications, New York, John Wiley and Sons, 1985. 

Another interesting development is the recent use of tritium NMR spectroscopy to study the removal of hydrogen from a chiral methyl group. In the degradation of L-valine, isobutyryl-CoA, 163, is an intermediate this metabolite is then oxidized to metacrylyl-CoA, 164. In the oxidation, one hydrogen is removed from C-2, and one from the pro-S methyl group on the same carbon. To determine the stereochemistry... 

Recently, the application of more advanced synthetic procedures and the availability of new analytical techniques, in particular tritium NMR spectroscopy, have allowed the preparation of a number of mechanistically useful multitritiated species. 

The examples and spectra quoted in the foregoing account will have indicated the excellent NMR properties of the tritium nucleus for high resolution studies. Tritium NMR spectroscopy provides a rapid and nondestructive technique for locating the positions and amounts of the isotope in [ H]compounds, and for... 

Evans, E.A. WarreU, D.C. Elvidge, J.A. and Jones, J.R., Handbook of Tritium NMR Spectroscopy arul Applications John WUey Sons, Ltd Chichester, 1985. 

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