Tritium cryoprobe

Fig. 1. (A) NMR spectrum ( H decoupled) of tritiated o-methoxyacetophenone (0-CH3O-C6H4COCH2T, llpCi) with a proton/tritium cryoprobe at 533.5MHz,...

Figure 1 NMR spectra of tritiated o-methoxyacetophenone (o-MeO-C6H4COCH2T, 68pCi) observed (A) at 320.13MHz with a 5 mm duai-proton/tritium probe, (B) at 533.5 MHz with a 5 mm ieak-proof seiective excitation proton/tritium probe, (C) at 533.5 MHz with the 5 mm seiective excitation proton/tritium cryoprobe, and (D) the same compound at iower activity (11 pCi) using the 5 mm seiective excitation proton/tritium cryoprobe at 533.5 MHz. (Reproduced with permission from Bioxsidge JP, Garman RN, Giiiies DG, Jones JR, and Lu SY (2004) Deveiopment and appiication of a tritium cryo-probe H NMR studies at the microcurie (megabecquerei) ievei of radioactivity, in Dean DC, FiierCN, and McCarthy KE (eds.) Synthesis and Application of Isotopically Labelled Compounds, voi. 8. Chichester John Wiiey Wiiey.)...

The second development relates to NMR sensitivity. Improvements in spectrometer technology over the last 20 years of the twentieth century led to an approximate threefold increase in NMR sensitivity. Now with the development of cryoprobes there is the possibility of being able to reduce the measmement time by an order of magnitude, or more. This kind of benefit will be maximized for nuclei such as tritium that have an extremely low natural abundance. 

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