3,4,6-trisubstituted pyrid-2-ones

Michael Acceptor on Solid Phase (Route to 3,4,6-Trisubstituted Pyrid-2-ones)... 

Katritzky et al. [387] have presented a synthesis of 3,4,6-trisubstituted pyrid-2-ones starting with solid support-bound acetophenone, which was deprotonated with NaOCHs to give the corresponding enolate. The latter was condensed with various benzaldehydes to give the resin-bound chalcones [388], which then can react with benzotriazolyl acetamides [389] to give 3,4,6-trisubstituted pyrid-2-ones (Scheme 104). 

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