Triptolide cytotoxicity

The isolation of these antileukemic compounds encouraged Kutney and coworkers [173, 174] to develop a plant cell culture line of T. wilfordii that would hopefully produce these compounds in higher yield and under laboratory controlled conditions. In this line, this group have published that the stable cell line, coded as TRP4a, was shown to produce the cytotoxic diterpene triptolide (79) and tripdiolide (80) in yields that were 3 and 16 times greater, respectively, than those observed in the parent plant source. 

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