Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Triplets drug-likeness

From our studies, it can be assumed that Al is likely to play a role in switching off the FMR1 gene by inducing a helical transition from B- to 2-DNA, in addition to the factors involved in the massive expansion of CCG triplet repeats and hypermethylation. This may provide a clue for the discovery of new drugs which convert Z- to B-DNA. It is hypothesized that chelation of metal ions like aluminum, demethylation of the triplet repeats, and acetylation of histones - if achieved - may make it possible to switch on the FMR 1 gene. [Pg.94]

See other pages where Triplets drug-likeness is mentioned: [Pg.5]    [Pg.218]    [Pg.266]    [Pg.270]    [Pg.266]    [Pg.270]    [Pg.260]    [Pg.260]    [Pg.318]    [Pg.367]    [Pg.217]    [Pg.224]    [Pg.242]    [Pg.364]    [Pg.164]    [Pg.1307]   
See also in sourсe #XX -- [ Pg.99 ]



SEARCH



Drug-like

Drug-likeness

Triplet drugs

© 2024 chempedia.info