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Triple asymmetric synthesis aldol reaction

A catalytic triple domino Michael-aldol-oxa-Michael reaction of acetaldehyde with ( -2-(2-nitrovinyl)phenols catalyzed by (R)-2- diphenyl [(trimethylsilyl)oxy] methyl pyrrolidine followed by a sequential one-pot Wittig, Michael/Wittig-Horner reactions with PPh3=CHC02Et was applied to the asymmetric synthesis of polyfunctionalized chromans (14EJO3076). [Pg.484]

Enders described a fascinating organocatalytic one-pot asymmetric synthesis of tricyclic compounds using a triple-cascade/Diels-Alder reaction sequence. Combination of dieneal 110 with enal 111 and nitro alkene 112 in the presence of a chiral amine catalyst results in a Michael/Michael/aldol condensation sequence to yield cycloaddition precursor 113. Cooling the reaction mixture and addition of a Lewis acid promotes the desired intramolecular Diels-Alder reaction to selectively afford the highly functionalized tricyclic target 114. ... [Pg.294]

See other pages where Triple asymmetric synthesis aldol reaction is mentioned: [Pg.265]    [Pg.265]    [Pg.265]    [Pg.55]    [Pg.218]    [Pg.47]    [Pg.1365]    [Pg.1365]   
See also in sourсe #XX -- [ Pg.2 , Pg.265 ]

See also in sourсe #XX -- [ Pg.265 ]

See also in sourсe #XX -- [ Pg.265 ]

See also in sourсe #XX -- [ Pg.2 , Pg.265 ]

See also in sourсe #XX -- [ Pg.265 ]



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Aldol reaction synthesis

Aldol syntheses

Asymmetric aldol reactions

Asymmetric synthesis reactions

Triple asymmetric synthesis

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