Triphenylmethyl group, hydrogenolysis

The 2,4,6-trimethylbenzyl ester has been prepared from an amino acid and the benzyl chloride (Et3N, DMF, 25°, 12 h, 60-80% yield) it is cleaved by acidic hydrolysis (CF COOH, 25°, 60 min, 60-90% yield 2 N HBr/HOAc, 25°, 60 min, 80-95% yield) and by hydrogenolysis. It is stable to methanolic hydrogen chloride used to remove A-o-nitrophenylsulfenyl groups or triphenylmethyl esters. ... [Pg.257]

Hydrogenolysis of a triphenylmethyl protecting group was carried out over 10% Pd/C in dry CH2Cl2 at 25°C under 4 atm hydrogen pressure for 4 days.172... [Pg.142]

The triphenylmethyl function, also known as trytil (Trt), is a valuable bulky protecting group for peptide chemistry. Trytil groups confer acid-labile protection onto amines, but effective removal can also be achieved by catalytic hydrogenolysis. [Pg.170]

The triphenylmethyl (trityl) group remains the most frequently used for the temporary protection of primary hydroxyl groups (for review see Refs. [2, 3, 254]) which can be conveniently regenerated from the corresponding ethers by mild acid treatment or by hydrogenolysis. Moreover, good crystallizing properties of trityl ethers, easy... [Pg.234]

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