Trinuclear Platinum Anticancer Agents

2 Dinuclear and Trinuclear Platinum Complexes as Anticancer Agents 

3 Biological Activity of Polynuclear Platinum Complexes. Summary and p53 Status of Human Tumors Treatable by BBR3464 

---

Farrell, N. Spinelli, S. Dinuclear and Trinuclear Platinum Anticancer Agents In Uses of Inorganic Chemistry in Medicine, Farrell, N., Ed. The Royal Society of Chemistry Cambridge, 1999, pp 124-134. 

The affinity of platinum(II) for N-donor ligands is well established. There are numerous examples in the literature of mono-, di-, and trinuclear platinum(II)-ammine and alkylamine complexes, most of which are structural analogues of the anticancer agent, mplatin (cis- PtCl2(NH3)2]), and the corresponding trans isomer. Selected novel complexes and synthetic methods are presented below. 

Farrell, N. P. Qu, Y. Bierbach, U. Valsecchi, M. Menta, E. Structure-activity Relationships within Di- and Trinuclear Platinum Phase I Clinical Agents In Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug Lippert, B., Ed. Verlag, 1999, pp 479 196. 

Structure-Activity Relationships Within Di- and Trinuclear Platinum Phase-I Clinical Anticancer Agents... 

Dinuclear and trinuclear platinum complexes represent a new class of anticancer agents, distinct in DNA-binding and profile of antitumor activity from their mononuclear counterparts. The dinuclear motif was first reported in 1988 and consisted of two m-PtCl2(NH3) units linked by a flex-... 

N. Farrell, Y. Qu, U. Bierbach, M. Valsecchi, and E. Menta, Structure-activity Relationships Within Di-and Trinuclear Platinum Phase-I Clinical Anticancer Agents, in 30 Years of Cisplatin, Chemistry and Biochemistry of a Leading Anticancer Drug , ed. B. Lippert, Wiley VCH, Weinheim, 1999, p. 479. 

---