Trimetozine, synthesis

Because FIC1 is formed during the reaction, two equivalents of the amine must be used. One equivalent reacts with the acid chloride, and one equivalent reacts with the HC1 by-product to form an ammonium chloride salt. If, however, the amine component is valuable, amide synthesis is often carried out using 1 equivalent of the amine plus 1 equivalent of an inexpensive base such as NaOH. For example, the sedative trimetozine is prepared commercially by... 

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