Trimethylsilyl Ethers of Alditols

The resolution of methyl ethers of D-glucitol as their acetates, trifluoro-acetates, or trimethylsilyl derivatives was examined. For the last compounds, it was found that 2,6- and 3,6-dimethyl ethers are only partly separated, and that the 2- and 3-monomethyl ethers are not separated at all. This result accords with the observation that trimethylsilyl ethers of alditols are often poorly resolved. 

Investigations that have involved separations of trimethylsilyl ethers of alditols are listed in Table XXV (see p. 88) Tables XXVI (see p. 89), XXVII (see p. 99), and XXVIII (see p. 100) record separations based on alditol acetates, trifluoroacetates, and aldononitrile acetates, respectively. The retention times of alditol acetates have been tabulated. ... 

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