Trimethyl anilinium hydroxide

On-column methylation of barbiturates, hydan-toins, and some carboxylic acids can be achieved by injecting the sample mixed with 0.2M trimethyl-anilinium hydroxide in methanol. For carboxylic acids, the sample can be dissolved in 14% boron trifluoride in methanol and heated at 60 to 100° for 30 minutes. After evaporation of the bulk of the methanol, the mixture is diluted with a few millilitres of water and the methyl derivative extracted with a small volume of hexane. 

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