Trimethoxysilane, toxicity

Triethoxysilane and especially trimethoxysilane are rather toxic compounds (they may cause blindness if allowed to get into contact with eyes) and therefore care must be taken in their handing. Both need to be manipulated very carefully with suitable gloves, eyes face protection, in a well ventilated fume-hood. However, both can be handled without problems via syringe techniques. 

Aryltrimethoxysilanes, for use in cross couplings, can be prepared by a palladium-catalysed reaction of aryl iodides with trimethoxysilane, but this silane is extremely toxic ... 

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