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Trimethoprim interaction with DHFR

This data shows a noticeable drop in binding affinity for trimethoprim and chicken liver DHFR. Figure 8 illustrates steric interaction between the 5-OMe of trimethoprim (green) with the sidechain of Tyr 31 of native chicken liver DHFR (red). There is no steric interaction seen between the 5-OMe of trimethoprim (green) and the sidechain of Phe 30 of L. casei DHFR (red). (Right view chicken liver DHFR Left View L. casei DHFR) It is known from x-ray crystallographic results that the sidechain of Tyr 31 of chicken liver DHFR rotates to accommodate trimethoprim. ( ... [Pg.154]

Fleischman SH, Brooks CL. Protein-drug interactions Characterization of inhibitor binding in complexes of DHFR with trimethoprim and related derivatives. Proteins 1990 7 52-61. [Pg.292]

S. H. Fleishman and C. L. Brooks III, Proteins, 7, 52 (1990). Protein-Drug Interactions Characterization of Inhibitor Binding in Complexes of DHFR with Trimethoprim and Related Derivatives. [Pg.295]

See other pages where Trimethoprim interaction with DHFR is mentioned: [Pg.379]    [Pg.244]    [Pg.389]    [Pg.460]    [Pg.51]    [Pg.54]    [Pg.191]    [Pg.44]    [Pg.151]    [Pg.97]    [Pg.214]   
See also in sourсe #XX -- [ Pg.2 , Pg.97 ]

See also in sourсe #XX -- [ Pg.97 ]



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