3.3.3- trifluoropropene oxide

Alkene insertion between the carbonyls of benzils (57) has been achieved by Michael addition catalysed by cyanide ion, as depicted in Scheme 3.55 a-Cyanocarbanions, from R1R2CHCN-BuLi in THF, have also been used to effect regiospecific ring opening of 3,3,3-trifluoropropene oxide to form CF3CHOHCH2CCNR1R2 diastereoisomers 56... 

The absolute configuration of other compounds [CF3CH(OH)R R=Me, Et, Bu, C7H15] was determined from S-(-)-trifluoropropene oxide, which was produced from the direct oxidation of 3,3,3-trifluoropropene with microorganism. 

Modification of Chiral Fluorinated Building Block (S)-Trifluoropropene Oxide... 

A dipolar cycloaddition of a steroidal nitrile oxide to trifluoropropene, followed by reductive hydrolysis, was used to prepare the trifluoromethyl cholestanone... 

Mixed-metal catalysts based on 002(00)9 have proved effective In the synthesis of N acyl amlnoaclds, starting with either allylic alcohols, oxiranes (eqn.15) or trifluoropropene. The oxidative carbonylatlon of organomercury compounds Is subject to solvent effects. The Pd catalysed carbonylative cross-coupling of aryl Iodides with triIsobutylaluminium gives secondary benzyl alcohols a variety of functional groups are tolerated.Carbamate esters... 

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