TFMSA trifluoromethanesulfonic acid

The relevance of Pt-OH formation to the change in the Tafel slope has been demonstrated by varying the content of water in the electrolyte [Murthi et al., 2004]. The experiments were performed in H20/trifluoromethanesulfonic acid (TFMSA) mixtures with several water/acid molar ratios. Whereas at high water contents the usual change in the Tafel slope from —112 to —59 mV/dec observed in aqueous solutions of H2SO4 and HCIO4 took place, at low water contents no change in the Tafel slope was observed. This corroborates the involvement of water in the formation... 

Fluorenone derived linker 17 prepared in two steps was coupled to aminomethyl-PS via DIPCDI [21]. Due to the presence of an electron-withdrawing carboxamide group, the release of carboxylic acids from this support requires strong acids, such as trifluoromethanesulfonic acid (TFMSA) (Scheme 1). Insertion of an oxygen adjacent to the biphenyl rings to the fluorenone scaffold provides xanthene 18 handle [22]. The oxygen is strategically located to decrease the acid concentration required... 

Solvents and scavengers methylene chloride (DCM), trifluoroacetic acid (TFA), A,A-diisopropylethylamine (DIEA), 100% ethanol, iV,A-dimethylformamide, di-methylsulphoxide (DMSO), acetonitrile, trifluoromethanesulfonic acid (TFMSA), dimethylsulfide (DMS), p-cresol, dimercaptoethane. 

Boc-SPPS normally relies on graduated acid-lability between the Boc (removed with TFA) and the linkage to the support (typically cleaved with HF or, alternatively, trifluoromethanesulfonic acid, TFMSA). In contrast, Fmoc-SPPS often displays an orthogonality [15] between the conditions for removal of the Fmoc protecting group (e.g., piperidine) and the conditions required for release from the support (often TFA). In the following, we will focus on Fmoc-SPPS. 

All solutions need to be prepared using deionized water. Trifluoromethanesulfonic acid (TFMSA), thioanisole, and other reagents have to be of analytical and chromatography grades ... 

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