Triflouroacetic acid

Both triflouroacetic acid and sulfur trioxide will cause very severe skin burns, and their vapors are extremely irritating. Sulfur trioxide is such a strong dehydrating agent that it chars organic material, and its heat of dehydration is so high that it will start a fire if spilled on wood, which could prove fatal were flammable solvents in use at the time or stored nearby. 

Diethyl amine Fmoc-Ser-OH Boc-Leu-OH Fmoc-Trp-OH Flydrazine Piperidine Triflouroacetic acid Potassium cyanate... 

Columns with a photodiode array detector and Millennium software were used for HPLC analysis. For reversed phase HPLC with a gradient system, a C18 pBondapak column (3.9 mm x 300 mm Waters) and Sphcrisorb ODS 2 (RP18,250 mm x 4 mm, 5 pm Waters) with a photodiode array detector were used. The mobile phases used for Ho-DOTA were H,0 (solvent A) and MeCN (solvent B) with an elution gradient of 0-100% B from 0 to 30 min. The mobile phases used for "Ho-DOTATATE were 0.1% triflouroacetic acid-H2O (solvent A) and 0.1% TFA-MeCN (solvent B) with the following elution gradient 0% B for 3 min, 0-50% B over 10 min, 50% B over 10 min, 50-70% B over 3 min, 70% B for 4 min. 

The anisotropic films exhibited two glass transitions whose temperature location and ACp agree well with values reported by Menzcel and Wunderlich (J12,itQ.). The first heat DSC scan of the EK60ca film shows a broad endotherm above the first glass transition roughly corresponding to the vaporization of about 3 wt% triflouroacetic acid. The presence of 3 wt% residual solvent was confirmed by thermogravimetric analysis (TGA). 

EK60ca 60 Solution cast from 10 wt.% triflouroacetic acid solution. Dried under vacuum at 50 °C for 7 days. Dried at room temperature for 6 months. 

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