Trididemnic acids

Two metabolites which were called trididemnic acids A (167) and B (168), were isolated from a Northeast Pacific ascidian Trididemnum sp. [127]. Xanthurenic acid (169) co-occurred with the trididemnic acids suggesting biosynthesis from tryptophane no activity data was reported. 

Tridehydrofangchinolinium, in F-lOOOl Tridensene, T-20151 Trididemnic acid A, T-20152 Trididemnic acid B, in T-20152... 

Trididemnic acid A 10(8). 1 COjH OH Bz OH C17H11NO6, EIHRMS, Trididemnum sp. (ascidian)... 

Perspicamides A and B are rare examples of quinoline-2-carboxylic acid derivatives (cf trididemnic acids, see above). Isolated from the AustraUan species Botrylloides perspicuum, these derivatives have no particular biological activity (McKay, Carroll, and Quinn, 2005). Trididemnic acids and the perspicamides, however, are related to kinurenic add, an anti-excitotoxic and anticonvulsant that was isolated from the spedes Botryllus schlosserl with other polar derivatives, and this is their first identification in a marine organism (Usov et al, 2002). 

Dilip de Silva, E., Miao, S., Andersen, R.J., Wayne, L., and Clardy, J. (1992) Trididemnic acids A and B, aromatic alkaloids from the Northeastern Pacific ascidian Trididemnum sp. Tetrahedron Lett., 33, 2917-2920. 

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