Tridentate Ligands Containing 1,4-Disubstituted

Tridentate Ligands Containing 1,4-Disubstituted-1,2,3-Triazole Units... 

Tridentate Ligands Containing One 1,4-Disubstituted-1, 3-Triazole Unit... 

It is clear that the CuAAC click reaction can be exploited to rapidly synthesize families of functionalized ligand architectures, and this synthetic versatility could lead to many potential applications. However, before the full potential of these click ligands can be realized, an understanding of the coordination properties of 1,4-disubstituted-l,2,3-triazoles is required. In the following sections, we will examine the coordination properties of monodentate, bidentate, tridentate, and polydentate ligands containing 1,4-disubstituted-l,2,3-triazole units. 

A range of tridentate click ligands have been synthesized and characterized. While the majority of these ligands contain two or three 1,4-disubstituted-1,2,3-triazole units, there are a few examples of tridentate chelators that contain one 1,2,3-triazole unit. 

Adolfsson et al. have used related amino acid-derived mOTio-l,4-disubstituted-1,2,3-triazole containing tridentate chelators, 86, as ligands in ATH reactions (Fig. 19) [190]. The authors screened a family of ligands with different steric and electronic properties in the Rh(I)-catalyzed ATH of acetophenone to 1-phenyethanol and showed that the use of these click catalysts led to good conversion (62-79%) and high ee (71-93%). 

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