2.2.2- Trichloroethyl carbamates protect amines

Troc protecting groups are easy to remove, which is an advantage associated with the use of 2,2,2-trichloroethyl-A/-tosyloxy-carbamate as a nitrene precursor cort5)ared to arylsulfamate, which require harsh reaction conditions to obtain the free amine. Both amantadine (R = H) and memantine (R = Me) hydrochloride were prepared in quantitative yields from the corresponding Troc-protected amino compounds (eq 5). ... 

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