Triazolic ribonucleosides

Syntheses of triazolic ribonucleosides 37 have also been reported following a similar approach. After preparation of enamines 36 by condensation of acetyl acetone 8 or ethyl acetonate 5 with 5-amino ribofuranose 35, diazotation with MsNa delivered triazoles 37a and 37b in 74% and 70% yield, respectively (Scheme 12) [45]. 

Abbreviations used PRPP, phosphoribosylpyiophosphate PR-ATP, phosphoribosyl-ATP PR-AMP, phosphoribosyl-AMP PR-AIC, 4-amino-S-iinidizolecarboxainide ribonucleotide ribosyl-AIC, 4-amino-S-imidazoIecarboxamide ribonucleoside TRA, 1,2,4-triazole-3-alanine. 

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