Triazinedione synthesis

Pyrimido[5,4-e][l,2,4]triazine-5,7-dione, N-methyl-applications, 3, 456 Pyrimido-1,2,4-triazinediones synthesis, 2, 78 Pyrimidotriazines synthesis, S, 338... 

Hydrazinobenzimidazole derivative 336 was treated with oxocarboxylic acids to give a hydrazone 337 which underwent ring closure to the fused triazinone 338 <2000JME96, 2001JME316>. Reaction with dialkyl oxalate allowed the synthesis of the triazinedione derivative 339 <2001JME4359>. 

Triazinedione is synthesized from formylbiuret (85 Scheme 51) (60AG836). The latter compound has been postulated as an intermediate in the reaction of biuret with ethyl formate (61CCC2519). The synthesis is also effected by treatment of A AT -dicarbamoylform-amidine (86) with sodium ethoxide (Scheme 51). 

Cyclocondensation between l,2-dihydroquinoxalin-2-ones and l,2,4-triazine-3,5-dione derivatives involves the carbonyl group of the 1,2,4-triazinedione and not the carbonyl group of the quinoxalinones <04JHC597>. New examples of the synthesis of pyridine and 2,2 -bipyridine derivatives from a variety of substituted 1,2,4-triazines through Diels-Alder reactions have been described <04T8893>. 

Burger H, KopUn R, Pawelke G (1983) Reaction of perfluototrimethylamine with antimony pentafluoride. Synthesis and X-ray structure of perfluorinated hexahydro-triazinedione derivative. J Fluor Chem 22 175-183... 

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