Triamterene Indometacin

Triamterene Indometacin Potentiation of nephrotoxicity, including subjects with normal renal function Combination contraindicated... 

Potassium-rich foods (e.g. bananas) can cause hyperkalaemia if the medication(s) used also tend to cause hyperkalaemia, for example potassiumsparing diuretics (triamterene, spironolactone), ACE inhibitors (captopril, enalapril, etc,), angiotensin receptor blockers and indometacin,... 

The concurrent use of triamterene and indometacin has, in several cases, rapidly lead to acute renal failure. An isolated case of renal impairment with diclofenac has been reported in a patient taking triamterene plus a thiazide. A case of exercise-induced acute renal failure has also been reported in a patient taking ibu-... 

A study in 4 healthy subjects found that indometacin 150 mg daily given with triamterene 200 mg daily over a 3-day period reduced the creatinine clearance in 2 subjects by 62% and 72%, respectively. Renal function returned to normal after a month. Indometacin alone caused an average 10% fall in creatinine clearance, but triamterene alone caused no consistent change in renal function. No adverse reactions were seen in 18 other subjects treated in the same way with indometacin and furosemide, hydrochlorothiazide or spironolactone. Five patients are reported to have rapidly developed acute renal failure after receiving indometacin and triamterene, either concurrently or sequentially. " ... 

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