Tri-O-benzoyl-P-D-ribofuranosyl azide

Reduction of tri-O-benzoyl-p-D-ribofuranosyl azide (70) was accompanied by acyl migration and anomerization, yielding the a amide 205 (the... 

The triazolo[4,5-d]pytimidine nucleoside 12 was obtained, albeit in low yield, by cyclization of tri-O-benzoyl-P-D-ribofuranosyl azide with 2-r-butyl-4-pyridyne generated in situ - ... 

Based on similar synthetic pathway and experimental reaction conditions, the preparation of ribosylated 1,2,3-triazole derivatives 83 has been described with moderate to good yields. The starting materials are the ketene aminals 81 and the 2,3,5-tri-O-benzoyl-p-D-ribofuranosyl azide 82 (Scheme 26) [69]. 

Later in 1986, Townsend et al. prepared 5-ainino-l-(2,3,5-tri-0-acetyl-P-D-ribofuranosyl)-l,2,3-triazole-4-carboxamide 19 [8], which is a crucial intermediate for the synthesis of 2-azacoformycin, by the 1,3-dipolar cycloaddition of cyanoacetamide 10a and 2,3,5-tri-O-benzoyl-p-D-ribofuranosyl azide 18 under strongly basic conditions (Scheme 4.6). A complete removal of the benzoyl protecting groups from the crude nucleoside product (partial removal of these groups had occurred during the course of the reaction) was effected and then followed by an in situ acetylation afforded the triazole 19 in 37% overall yield [8]. 

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